6 Best Diet Pills and OTC Weight Loss Supplements That Actually Work

PrimeShred diet pills at a glance

• Excellent for increasing thermogenesis
• Supports sustained metabolism boost
• Guaranteed weight loss pills, especially for men looking to get shredded and put on muscle
• Preserve existing muscle while building muscle and losing fat
• Clinically proven ingredients
• Get rid of those last few pounds of stubborn fat around the waistline
• Great for improving energy and focus
• Smash through frustrating plateaus in terms of fat loss and muscle gain

Full review

PrimeShred is easily among the “best weight loss supplements” for men looking to get lean, or more specifically, get “cut up” but without the energy loss or lean muscle mass loss, which is typically associated with ‘hard dieting’ and fat loss cycles. 

If you’re someone who’s actively trying to reduce bodyfat percentage, while improving your muscle to fat ratio and improve your strength levels as well as lean muscle mass, you absolutely need PrimeShred in your arsenal!

The ingredients in PrimeShred’s fat burning pills also help to preserve your existing muscle mass, as you continue to destroy fat and build more muscle. Here’s how the formula works to help men annihilate fat and build muscle at the same time:

Stimulus of lipolysis: The process in your body where fat cells are broken down to be used for energy is known as lipolysis. The formula in PrimeShred has powerful scientifically-proven ingredients which directly stimulate lipolysis, which means you can get rid of those last few ‘pockets’ around the lower back, sides and lower abdomen – the areas which tend to not respond so well to diet and exercise alone, especially during those crucial last stages of your fat loss cycle.

Natural weight loss pills for energy production: Most diet pills, including even some of the best over the counter weight loss pills or “guaranteed weight loss pills” rely too much on stimulants like caffeine to provide you energy. Unfortunately, they don’t include anything to offset the downside of caffeine: once it wears off, you tend to feel shaky and jittery. 

PrimeShred contains relatively low doses of green coffee and tea extract, as well as a powerful herb called Rhodiola rosea and a naturally-occurring amino acid, L-theanine. All of these work collectively to offset the effect of caffeine, not just enhancing its effect in a way but also smoothing it out, for sustained and steady energy, more mental clarity, and none of the shakiness or jitters afterwards. 

Faster fat burning overall: Ingredients like L-tyrosine, vitamins B3, 6 and 12, as well as chlorogenic acid and cayenne acid help to boost your metabolism, promote better fat burning and keep your body in a sustained state of fat burning after exercise too. 

PrimeShred is completely free of animal-derived ingredients – so, it’s meat, egg and dairy-free as well as gluten-free, soy-free and GMO-free. It also contains no preservatives, colours or artificial sweeteners, making it one of the best natural weight loss pills currently available on the market. 

What are the key ingredients in PrimeShred?

• Green coffee
• Green tea extract
• Rhodiola Rosea root
• B-vitamin complex
• Caffeine anhydrous 
• L-tyrosine
• L-theanine
• DMAE
• BioPerine
• Cayenne pepper

PrimeShred has quickly climbed to the top as the best diet pills for men this year, particularly for getting shredded. The ingredients have been cleverly lab-engineered to help the body kickstart the lipolysis process – for instance, the caffeine, capsaicin, green tea, and L-tyrosine all unlock the body’s production of epinephrine and norepinephrine – two key hormones that kickstart the lipolysis process. 

Furthermore, the non-prescription weight loss pills for men also help to reduce triglyceride levels in the blood, meaning that your body will be better primed to shrink and eventually flush out fat cells from your system, giving you a harder, more toned and more muscular look. 

The formulation also helps to significantly speed up the metabolism – the caffeine, green coffee and cayenne pepper in PrimeShred are all key to increasing thermogenesis, while the B-vitamins help you convert the calories you ingest into energy rather than fat. Most people have a hard time losing the last few pounds of fat or keeping it off because half the calories they consume convert into fat! With PrimeShred as your “go-to best supplement for weight loss”, you’ll never have to worry about that. 

At last, ingredients in this diet supplement like green tea catechins, for instance, can potentially aid the body in using more fat stores for energy, ultimately contributing a great deal to both your fat loss and muscle-building goals. 

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#4. Instant Knockout CUT – Best Thermogenic Fat Burner for Athletes and ‘Active People’

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Instant Knockout CUT : Best diet pills for athletes at a glance

• Powerful fat loss diet supplement for athletes
• Helps to almost “melt away” stubborn fat
• Fine selection of natural and high-quality ingredients
• Supercharges metabolism
• Kicks up thermogenesis for faster fat loss
• Reduces appetite and cravings 
• Helps to build harder, more toned muscles
• Increases the body’s maximum fat burning potential when combined with the right diet and exercise programme
• Highly effective alternative to using a banned weight loss substance or drug
• Weight loss ingredients are natural and high-quality
• Easily one of the best weight loss pills for athletes and active men

Full review 

Instant Knockout CUT has proven to be yet another “best over the counter weight loss pills” this year, primarily geared towards male athletes, bodybuilders, sportsmen and casual gym-goers alike. Interestingly, these weight loss pills (that actually work) were originally developed to help professional boxers, fighters and MMA practitioners get shredded and build some extra muscle before an upcoming event, hence the name “Instant Knockout”. 

At its core, Instant Knockout CUT functions primarily as a thermogenic fat loss supplement, with the ingredients specially formulated to help ‘active men’ burn fat and lose weight faster. Many athletes, sports professionals and everyday working men as well as women have already reported faster metabolism, more defined muscles, increased thermogenesis and reduced cravings after using these over the counter diet pills. 

Instant Knockout CUT contains nine completely natural ingredients to help athletes (males in particular) target weight loss in a healthy and sustained way. One of these is a dietary fibre, glucomannan – often found in other leading weight loss products as well – and a key ingredient to help with appetite suppression, with the added benefit of making you feel fuller throughout the day.  

If you’re planning to take the natural weight loss pills for several months, like most athletes do for optimal results, then you might benefit from Instant Knockout’s subscription deal where you might save a good 10%. 

What are the key ingredients in Instant Knockout?

• Black pepper extract
• Green tea extract 
• Caffeine
• L-theanine
• Cayenne pepper
• Vitamins B6, D3 and B12
• Glucomannan 

Instant Knockout CUT is produced solely in the US, with each bottle having 100% natural weight loss pills with vegan-friendly ingredients at the core. Its prowess as potent fat burning pills is irrefutable as is its potential to help men build more muscle and prepare themselves for athletic competition. 

Whether you’re a pro fighter, athlete, sportsman or casual gym-goer looking to gain an edge in your workouts and burn extra fat, Instant Knockout are “guaranteed weight loss pills” to help you knock off those stubborn layers of fat to reveal hard and toned muscle. 

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#5. TrimTone – Metabolism Booster for Women

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TrimTone diet pills for women at a glance

• Specifically formulated to help women burn off stubborn layers of fat
• Helps to control sugary and carb cravings between meals
• Helps women speed up metabolism and burn more calories at rest
• All natural ingredients with no side effects
• Helps to unlock the female body’s potential to use stored fat for energy
• Full refund within 100 days if not satisfied

Full review

TrimTone is an incredible women’s weight loss pill which helps to curb hunger and cravings, and helps in naturally boosting the metabolism without the need for any prescription drugs. Women often experience a ‘metabolic crash’ and serious food cravings more than men when on a weight loss diet and exercise programme, and this is where TrimTone proves to be an incredible diet supplement. 

Dealing with a slow metabolism during a weight loss phase means that your road to achieving your target weight and fat to muscle ratio can be seriously hampered. If any of this sounds a bit technical then in plain terms, your metabolism is what converts the foods and drinks you consume into energy. The total number of calories your body uses up for energy is referred to as BMR – basal metabolic rate. So, the higher your BMR, the more calories you’re going to burn, especially during intense physical activity.

Where TrimTone truly shines as ‘diet pills for women’ is its ability to boost the metabolism, particularly in women. Each bottle contains natural weight loss pills which offers women an increase in their BMR, which in turn, increases the rate at which they burn fat (both during exercise and at rest), and reduces appetite along with those nagging sugar cravings. 

Today, you’ll hardly find any women’s weight loss pills that work as an effective fat burner without including a lot of caffeine or heavy doses of other stimulants. TrimTone, on the other hand, are 100% natural weight loss pills, helping women to kick their metabolism into high gear, curbing those obnoxious cravings during a restricted calorie phase, and ultimately, keeping them on track during the weight loss cycle. 

What are the key ingredients in TrimTone?

• Glucomannan 
• Caffeine
• Green coffee
• Green tea
• Grains of paradise (a metabolism-boosting herb)

There are far too many diet pills for women available on the market today as “over the counter diet pills” and “fast weight loss pills” – but almost none of them contain all-natural ingredients. The natural ingredients in TrimTone, however, work by stimulating the body’s thermogenic potential, or thermogenesis, in other words – giving you the energy you need to not only workout efficiently on a low-carb, low-calorie diet but also giving you plenty of energy throughout the day without the need to consume extra calories.  

One of the key ingredients in these best diet pills (for women) is glucomannan, a natural dietary fibre which is also included in many other leading “best weight loss supplements”. This fibre helps to control the appetite and curb feelings of hunger and food cravings by making you feel fuller and for a lot longer too. This is why it’s essential to take your TrimTone dose with the very first meal each day so that you’ll have sustained energy release with no cravings to deal with throughout the day. 

TrimTone also contains a small amount of caffeine (from green coffee and green tea) to increase your metabolic rate and further help in stimulating thermogenesis, keeping your body in a fat-burning state around the clock. Did you know that caffeine taken in small amounts via diet pills can increase lipolysis? As you read in one of the earlier reviews in this article, lipolysis is the process of breaking down body fat. Caffeine certainly helps with that and as an added bonus, you also feel more energized and alert throughout the day, and not deal with any cravings, because you already have the energy and focus you need. 

If you’ve just started your weight loss journey, then TrimTone are guaranteed weight loss pills – you should see results within weeks, provided your diet and exercise are on track. 

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#6. PhenGold – Best Appetite Suppressant Supplement

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PhenGold fat burning pills at a glance

• Incredible formula helps reduce appetite and control cravings
• Supercharges metabolism to keep you in a calorie burning mood
• Increases mental clarity and focus when on a low-calorie diet
• All-natural vegan-friendly and GMO-free ingredients
• One of the best weight loss pills on the market right now
• Multi-action formula encourages the body to burn more fat
• Helps you burn more calories even when you’re asleep 

Full review

PhenGold offers currently the best weight loss pills on the market in terms of the appetite suppressing and metabolism boosting benefits it has. 

If we were to pick just one kind of weight loss pills based on these two benefits alone, we would go with PhenGold – that’s how effective it is for kicking up your metabolism and helping you control food cravings, all without any reported side effects. 

Since losing fat or even weight, for that matter, requires cutting down calories and increasing physical activity, it can often lead to a metabolic crash where your body no longer burns calories effectively for energy, because it’s constantly craving food. Staying on a low-calorie diet also means that those food cravings are going to be very hard to resist at times and you just can’t help but indulge a little. 

However, with PhenGold in your arsenal of weight loss pills (that actually work), you will never find yourself running into such problems, which can otherwise seriously derail the hard work you’ve put in so far and even throw you off track in regards to your ongoing and future weight loss goals. Sometimes, all you need is a quality appetite suppressant and metabolic booster to accomplish your weight loss goals, and PhenGold fits the bill very nicely indeed. 

What are the key ingredients in PhenGold?

• L-theanine
• Green tea
• Green coffee
• Vitamin B3, 6 and 12
• Rhodiola rosea
• Cayenne pepper
• L-tyrosine
• Dimethylaminoethanol (DMAE)
• Caffeine anhydrous
• BioPerine

PhenGold’s high-quality, all-natural ingredients trigger fat-releasing hormones in the body, helping you eliminate unwanted bodyweight and particularly stubborn fat, when combined with the right weight loss diet and exercise programme. 

However, where it truly stands out as the best over the counter weight loss pills is its ability to speed up the metabolism, helping you burn more fat not only throughout the day and while working out, but also when you’re asleep. And, the appetite suppressants in the formula will not just curb your cravings between meals but also make you feel fuller for longer when you consume each meal. 

The energy-boosting green coffee and green tea in the weight loss pills ensures that you get a steady stream of energy throughout the day, and none of the harsh ‘caffeine crashes’ or jitters that you experience as a result of taking a high-caffeine diet supplement or too much coffee. The L-theanine and L-tyrosine work as natural mood boosters to keep you alert, focused and motivated all throughout the day. 

PhenGold is easily among the best weight loss pills, especially when we talk about appetite suppression and metabolic boost, and you get a full money-back guarantee too. 

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How do I identify the Best Weight Loss Supplements?

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While the above product reviews on the best weight loss pills will certainly help you find the one which matches up with your individual goals, it’s also important to know some common attributes which separates an average diet supplement from the best supplements for weight loss:

• Look for all-natural ingredients

You will find that the best weight loss supplements will always have natural ingredients; therefore, you should always avoid weight loss pills which contain synthetic ingredients, such as:

• Ephedra – A Speed-like drug which contains ephedrine, which is an amphetamine-like compound similar to adrenaline. It has been banned in athletic competition as a result.
• Sibutramine – An appetite suppressant which was used to treat obesity but discontinued in many countries since 2010 due to undesirable side effects. Also goes by other names such as Reductil, Sibutrex and Meridia. 
• Hydroxycut – Not to be confused with the fat-burning supplement from MuscleTech, the actual medication can be potentially unsafe for anyone under 18 and warnings on current products with hydroxycut (robusta coffee extract) clearly state to seek medical conditions if any “unusual symptoms” occur. 
• Clenbuterol – Even though clenbuterol was originally developed as a sympathomimetic amine to treat breathing disorders, it has steroid-like effects, which has made it popular among professional bodybuilders for cutting fat. However, it comes with a range of side effects including anxiety, agitation, muscular cramps, insomnia and even cardiac arrest.
• Fenfluramine and phentermine – Also referred to as “fen-phen”, the anti-obesity treatment has been shown to cause heart valve and severe pulmonary hypertension problems in some instances. 

If the weight loss product manufacturer is offering a full money-back guarantee (no questions asked), then it means they are willing to stand by their product, which likely contains natural ingredients and is effective at what it claims to do. All the products we’ve reviewed on this list come with a minimum 60-90 day money-back guarantee. 

In short, watch out for the term proprietary blend – these are essentially “secret ingredients” or formulas, where the manufacturer does not wish to disclose the dosages of the ingredients. Resultantly, manufacturers with ‘proprietary blend’ marked on the label may be able to get away with advertising a specific weight loss product as having “x” ingredient to yield powerful “y” results, but in reality, may only have that so-called ingredient in trace amounts, but may even include something not mentioned on the label at all. 

So if you see the term proprietary blend, you can bet the manufacturer is hiding something. The best weight loss pills will always disclose their formulas and/or ingredients clearly with the appropriate dosage next to each ingredient. 

• Positive online reviews and customer testimonials

When buying fat burning pills, you should feel confident in knowing that you’re purchasing the right product. This is why it’s important to check review sites and customer testimonials both on the manufacturer’s-site and other sites and forums as well, so that you know you’re investing in a quality weight loss product. 

With that said, you may come across a bad review or two every now and then, but that’s nothing unusual as different people see different results, especially when they don’t follow the manufacturer’s specific instructions or fail to incorporate the right diet, lifestyle and exercise program. 

Different types of Weight Loss Supplements and Diet Pills to consider 

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Checking our “best weight loss supplements” product reviews is one way to find the right product for yourself. Knowing what they should offer or the ingredients they shouldn’t have is another way. However, it’s also important to understand the different categories of over the counter diet pills or diet supplements in order to better aid your decision:

These types of weight loss pills mostly focus on helping you suppress your appetite and fight cravings, so that you can continue to maintain your low-calorie diet, have enough energy to workout and recover, and not feel too moody or agitated due to the caloric restriction. 

Such types of diet pills will inhibit your body’s ability to store fat even though you will need a prescription and they mostly fall under the “drug” category and not “diet supplements” category. Bear in mind though that fat blockers are not designed to help you lose weight but rather, limit the total amount of fat your body absorbs so as to help you avoid obesity or too much weight gain. It’s certainly not a green light to eat whatever you please and not gain weight at all. 

Carb blockers work uniquely than any of the fat burning pills we’ve listed in the article. So, what they do is they block the enzymes in your system which digest starch and carbohydrates. Even though this is one way to stop weight gain, and perhaps, encourage weight loss to some degree, carb blockers should only be used as a last resort because your body does need starches and carbohydrates to help you recover from exercise. 

Thermogenic fat burners raise the internal core temperature of your body, which means your metabolic rate will go up to help you burn more calories. Many of the over the counter diet pills and fast weight loss pills we’ve listed in this article act as thermogenic fat burners, although you’d want to be careful if you’re suffering from any kidney problems, nursing or pregnant. 

Thermogenic weight loss pills are definitely effective at helping you shed weight, but they are not a long-term solution – you do need to make (and maintain) certain diet, lifestyle and nutritional changes. 

Final thoughts on the Best Weight Loss Pills and Diet Supplements in 2022 (Only Over the Counter)

While the above are all excellent choices when it comes to weight loss pills and diet pills, they are certainly not the “end all be all”. Why? Because even the best weight loss supplements can only help you so much – in the end, you need to have your entire lifestyle, fitness and nutritional protocols revolve around your health and fitness goals and not the other way around. 

A great OTC diet or weight loss pill will certainly help you get there, but they are only a part of the overall success equation.

Read More:

Best OTC Brain Supplements and Nootropics for Men and Women

Best Pre Workout Supplements for Men and Women 

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